Recent advances in microRNA-mediated gene regulation in chronic lymphocytic leukemia.
نویسندگان
چکیده
Chronic lymphocytic leukemia (CLL) is the most common leukemia in the western world and is a very clinically heterogeneous disease for which better prognostic biomarkers are needed. Current prognostic markers exhibit both biological and technical limitations. MicroRNAs (miRNAs) are small endogenous, non-coding 22-nucleotide regulatory RNAs that have been shown to modulate hematopoietic lineage differentiation and play important gene-regulatory roles in disease processes. In this manuscript, we review miRNA biology and the association of specific miRNAs with CLL.
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ورودعنوان ژورنال:
- Clinical biochemistry
دوره 46 10-11 شماره
صفحات -
تاریخ انتشار 2013